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Takeaways from Cleveland Clinic’s Collaboration with Khosla Ventures - American Hospital Association

Reported by Aha
Oct 21, 2025· 2 min read
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Key Takeaways
  • • Cleveland Clinic is forming a strategic partnership with Silicon Valley health tech investor Khosla Ventures, combining Cleveland Clinic's clinical expertise and biomedical research with Khosla's two decades of health care technology investing.
  • • Khosla Ventures portfolio companies can work with Cleveland Clinic providers to test and showcase new technologies at all stages, from clinical validation to commercial adoption.
  • • Cleveland Clinic has already entered customer agreements and commercial relationships with Khosla-backed companies and is evaluating several others for partnerships, investments and co-development.
  • • The collaboration focuses on four areas: AI and digital health, therapeutics and diagnostics, care delivery, and value-based models for Medicare, Medicaid and dual-eligible populations.
  • • Cleveland Clinic Innovations, which has transformed more than 900 technologies into licensed products and launched more than 100 spinoff companies since 2000, will support the partnership.
Summary
Cleveland Clinic is forming a strategic partnership with Khosla Ventures, the Silicon Valley health tech investor, according to the American Hospital Association. The collaboration pairs Cleveland Clinic's clinical expertise and biomedical research with Khosla Ventures' two decades of experience investing in health care technology companies.

Under the arrangement, Khosla Ventures portfolio companies can work with Cleveland Clinic providers to showcase and test new technologies at all stages, from clinical validation to commercial adoption. The source article notes this access gives startups a way to demonstrate value directly with clinicians. For Cleveland Clinic, the partnership offers a direct pipeline to emerging technologies in artificial intelligence, digital health and next-generation therapeutics.

The partnership will be supported by Cleveland Clinic Innovations (CCI), the health system's innovation arm. CCI has transformed more than 900 technologies into licensed products and launched more than 100 spinoff companies since 2000, and brings experience in intellectual property management, licensing and startup incubation. Cleveland Clinic has already entered customer agreements and commercial relationships with Khosla-backed companies and is evaluating several others for potential commercial partnerships, investments and co-development. The two organizations are also working to identify and incubate research opportunities that could lead to new companies.

One proposed venture would see Khosla Ventures lead technical development and recruiting, while Cleveland Clinic provides the clinical environment to test, refine and scale the service. The organizations have prioritized four areas: AI and digital health; therapeutics and diagnostics in cardiology, oncology, neurology and musculoskeletal care; care delivery models, including home-based services, multispecialty primary care and global second-opinion programs; and value-based models for Medicare, Medicaid and dual-eligible populations.

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Sources

1 outlet

AlphaMaven summarised this story from the reporting below. Each link opens the original article.

Aha Takeaways from Cleveland Clinic’s Collaboration with Khosla Ventures - American Hospital Association