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Quantitative equity investing is having a bit of a mid-life crisis. Notwithstanding 2021, some of the most popular quantitative strategies have recently fallen on tough times. Will the same approach that has worked for many of us for several decades continue to work in the future? In a world of seemingly unlimited data and far more computing power than many of us could have imagined decades ago, what tenets of the process should we retain? Here, we endeavor to